Pharmaceutical ayurvedic preparation

ABSTRACT

The present invention relates to a process on ayurvedic preparation comprising in the steps of subjecting silver, mercury, sulphur and arsenic trisulphide to the steps of detoxification, grinding the detoxified mercury and silver in the presence of a citrus juice and then adding detoxified sulphur and again subjecting to the step of grinding to obtain a greyish black powder, adding detoxified arsenic trisulphide thereto and subjecting to the step of grinding, imparting a shape such as a ball thereto, coating the ball with detoxified sulphur in the presence of a citrus juice and subjecting the coated ball to the step of slow firing, adding detoxified arsenic trisulphide and firing, repeating said step of addition and firing ground in a citrus juice such that the weight of the ball is reduced by at least 10% to obtain an intermediate, adding serpentive and delphenium root thereto.

FIELD OF INVENTION

This invention relates to a pharmaceutical ayurvedic preparation for thetreatment of leukemia. The preparation of the present invention has aparticular application for the treatment of acute mycloid leukemia,acute promyelcocytic leukemia and acute lymphoblastic leukemia. Thepresent invention also relates to a process for preparing thepharmaceutical ayurvedic preparation.

PRIOR ART

Chemical pharmaceutical preparations are normally prescribed fortreatment of leukemia. No prior public literature is known for anayurvedic preparation for treatment of leukemia.

OBJECTS OF THE INVENTION

An object of this invention is to propose a novel ayurvedic preparationfor treatment of leukemia.

Another object of this invention is to propose an ayurvedic preparationfor treatment of leukemia and which does not have any side effects.

DESCRIPTION OF THE INVENTION

According to this invention, there is provided a process for thepreparation of an ayurvedic preparation comprising in the steps ofsubjecting silver, mercury, sulphur and arsenic trisulphide to the stepsof detoxification, grinding the detoxified mercury and silver in thepresence of a citrus juice and then adding detoxified sulphur and againsubjecting to the step of grinding to obtain a greyish black powder,adding detoxified arsenic trisulphide thereto and subjecting to the stepof grinding, imparting a shape such as a ball thereto, coating the ballwith detoxified sulphur in the presence of a citrus juice and subjectingthe coated ball to the step of slow firing, adding detoxified arsenictrisulphide and firing, repeating said steps of addition and firingground in a citrus juice such that the weight of the ball is reduced byat least 10% to obtain an intermediate, adding serpentive and delpheniumroot thereto.

The expression detoxification used herein is not intended to imply thatsilver, mercury, sulphur and arsenic trisulphide are treated such as todetoxify the elements in the mixture stage, but to imply that suchelements do not exhibit any adverse side effects in the endpreparations.

In accordance with this invention, silver in a purified form which issubjected to a step of detoxification. Such a step of detoxificationconsists in converting silver bars into sheets and then to repetitivesteps of heating and introduction into sesame oil. By way of example andwithout implying any limitation, such a step of heating and introducinginto sesame oil is repeated several times, such as seven times.

Thereafter, the treated silver is again heated and then introduced intobutter milk. The step of heating and introduction into butter milk aftereach step of heating is also repeated several times, such as seventimes.

The partially detoxificated silver is again heated and then introducedinto cow urine and which step is repeated several times, such as seventimes.

The treated silver is again heated and introduced into a herbalcomposition. Such a step of heating and introduction into a herbalcomposition is again preferably repeated several times, such as seventimes. The herbal composition comprises amla, harar and behera andpresent preferably in equal parts.

The treated silver is again heated several times and then after eachstep of heating is treated with kutli. Such a step is also repeatedseveral times, such as seven times. The aforesaid step consits in thedetoxification of silver. The process of the present invention includesthe step of detoxification of mercury. For this purpose, an amalgam isfirst prepared from a mixture of copper, which may be in the form ofwire, in lemon juice and mercury. Preferably ½–⅛ parts of copper wire isadded to every one part of mercury which is then ground to obtain anamalgam. Such an amalgam is then subjected to a step of distillation toextract mercury therefrom. The step of grinding and distillation iseffected several times in order to obtain detoxified mercury. Preferablybut without implying any limitation to the step of detoxification iscarried seven times.

The next step is the process consists in the purification of sulphur.For this purpose, crystalline sulphur is introduced into a crucible andhaving melted butter therein. Preferably, equal amounts of melted butterand sulphur are introduced into the crucible and heated on a low fire.Trifla is then added to the mixture and whereby a scum of pure sulphuris formed and removed.

The process also comprises in introducing arsenic trisulphide disposedwithin a cotton cloth and introduced into a vessel containing calciumoxide solution and then into another vessel of pumpkin juice or viceversa. The arsenic trisulphide is heated in calcium oxide solution andpumpkin juice for a period of 3 to 5 hours, such as 4 hours and, thendried.

The next step in the process consists in grinding detoxicated silver andmercury in the presence of citrus juice, such as lemon juice, and suchthat detoxicated silver is dissolved in mercury. Preferably, one part ofdetoxicated silver is added to one part of mercury and ground in thepresence of lemon juice to form a powder. Thereafter, purified sulphuris added thereto and ground to greyish black powder. Preferably, onepart of purified sulphur is added thereto. Upon grinding and obtaining agreyish black powder purified arsenic trisulphide is added to thegreyish black powder in the presence of a citrus juice, such as lemonjuice, which is then subjected to a step of grinding to obtain a paste.Such a paste is shaped into balls and then air dried. Preferably, onepart of arsenic disulphide is added thereto.

The next step in the process consists in coating such balls with a pasteof sulphur in lemon juice.

Such a ball is introduced into an earthenware vessel which is sealedwith a strip of cotton and dipped in clay. The vessel is introduced intoa bed containing dry cowdung which is then fired such that thetemperature rises to a temperature of 500–600° C. and then graduallyreduces.

The vessel is then opened and arsenic trisulphide is added thereto inthe presence of lemon juice and subjected to the step of firing. Thestep of adding arsenic trisulphide and firing is repeated 30–60 time toobtain a more potent intermediate product, and such that the weight isreduced by at least 10%.

Such an intermediate product is thereafter added to serpentine anddelphenium root and ground in distilled rose water for approximatelyseven days repeated with sandalwood water for seven day and finally withlatakasturi water for seven days to obtain a paste which is then shapedinto balls.

Further objects and advantages of this invention will be more apparentfrom the ensuing example and clinical trials.

EXMAPLE

Silver, mercury, sulphur and arsenic trisulphide was detoxified in amanner as described hereinabove.

Thereafter, the ball was prepared consisting of:

-   detoxified silver=250 gms-   detoxified mercury=250 gms-   detoxified sulphur=500 gms-   detoxified arsenic    -   trisulphide=250 gms

The ball had a weight of 1250 gms and then provided with a coating ofdetoxified sulphur ground in lemon juice and such that the coated ballhad a weight of 1400 gms. Such a ball was then introduced into anearthen vessel or pot and sealed with a strip of cotton, dipped in clay.The vessel is introduced into a pit containing cow dung and fired. Sucha process was repeated as shown in Table 1 to product the intermediateproduct. Thereafter, the final product was prepared in a manner asdescribed herein above.

TABLE 1 PERIOD WT. GROUND WITH OF AFTER ARSENIC LEMON PERIOD WT.BEFOREFIRING FIRING VESSEL trisulphide Juice DAYS FIRING gm DAYS gm 1  0  0 01400 1 940 1 25 g 450 ml 6 1120 1 975 1 25 g 400 ml 17 1100 1 940 1 25 g400 ml 22 1050 1 940 2 25 g 400 ml 29 1110 1 930 2 25 g 450 ml 36 100 1975 2 25 g 400 ml 41 1070 1 940 2 25 g 400 ml 50 1040 1 940 2 25 g 450ml 58 1050 1 930 2 25 g 550 ml 67 1080 1 940 2 25 g 500 ml 73 1070 1 9502 25 g 750 ml 80 1070 1 970 2 25 g 750 ml 84 1050 1 970 2 25 g 800 ml 891060 1 940 2 25 g 900 ml 96 1080 1 950 2 25 g 900 ml 103 1100 1 1000 225 g 900 ml 110 1120 1 970 2 25 g 900 ml 116 1050 1 950 2 25 g 900 ml121 1020 1 950 2 25 g 750 ml 128 1050 1 990 2 25 g 800 ml 135 1080 1 9802 25 g 750 ml 140 1050 1 950 2 25 g 650 ml 148 1050 1 950 2 25 g 700 ml153 1020 1 950 2 25 g 700 ml 159 1080 1 980 2 25 g 650 ml 173 980 1 920

The results of clinical trials on patients with the preparation of thepresent invention were as follows:

TABLE 2 DETAILS OF THE PATIENTS WHO COMPLETED 90 DAYS OF TREATMENT FORACUTE PROMYELOCYTIC LEUKEMIA WITH PRESENT MEDICINE Category Fresh/Duration of Treatment Status after S.No. Name/Age Relapse From To 90days 1. ARK/41 F Sep. 09, 1997 Jan. 30, 1998 Complete remission on Dec.26, 1997 2. VR/40 F Dec. 04, 1997 Apr. 22, 1999 Complete remission onMar. 14, 1998 3. PK/50 F Dec. 04, 1997 Mar. 20, 1998 Complete remissionon Mar. 16, 1998 4. VC/48 R Dec. 22, 1997 Apr. 15, 1998 completeremission on Apr. 01, 1998 5. F/29 R Apr. 09, 1998 Dec. 07, 1998 Bonemarrow not done, blood report normal 6. NS/15 R Apr. 18, 1998 Jan. 30,1999 Complete remission on Jul. 25, 1998 7. PR/48 F Jan. 26, 1999 May15, 1999 Complete remission on Apr. 12, 1999 8. MS/28 R Feb. 19, 1999Jun. 15, 1999 Complete remission on Jun. 11, 1999 9. PS/29 R Mar. 25,1999 Jul. 05, 1999 Complete remission on Jul. 03, 1999 F-Fresh,R-Relapse

TABLE 3 DETAILS OF BONE MARROW OF THE PATIENTS WHO COMPLETED 90 DAYS OFTREATMENT FOR ACUTE PROMYELOCYTIC LEUKEMIA After 90 days of Ayurvedictreat- S.No. Name/Age Before Ayurvedic treatment ment 1. ARK/41 BMno.5239863, replaced with PS and BM no. abnormal promyelocytes-M3523986-D, is free of evidence of M3, normal hemopoitic cell 2. VR/40Bone marrow shows abnormal Bone marrow in promyelocytes-M3 remission, nopromyelocytic cells seen 3. PK/50 Bone marrow replaced with Bone marrowin abnormal promyelocytes-M3 remission with normal cells 4. VC/48 Bonemarrow shows hyper Bone marrow in granulated M3 cells remission withnormal hemopoitic cells 5. F/29 Bone marrow shows abnormal Bone marrownot promyelocytes-M3 done 6. NS/15 Bone marrow shows 60–65% Bone marrowin abnormal promyleocytes, APML remission, no relapse, N_(8–10),L_(3–5), MRBC APML cells identi- 25% fied, PS shows P₆₄L₃₃E₂M₁ 7. PR/48Bone marrow shows hyper Bone marrow shows granulated promyleocytesnormal hemopoitic AML-M3 with mild megalo- blastic change. There is nomorphological evidence of residual leukemia 8. MS/28 Bone marrow inrelapse- Bone marrow shows AML-M3 normal hemopoitic. No leukemic cellsidentified 9. PS/29 Bone marrow shows total Bone marrow showsreplacement by abnormal hyper normal hemopoitic granular promyleocytescells of all series. No evidence of leukemia seen 10. MN/30 Bone marrowshows abnormal Bone marrow shows promyelocytes along with normalhemopoitic few normal neutrophils- cells in all AML-M3 relapse series.No evidence of residual leukemia

TABLE DETAILS OF BLOOD REPORT OF TREATED APML CASES S. Blood After 30After 60 After 90 No. Name/Age report First day days days days 1. ARK/41Hb gm % 7.1 9.9 13.5 14.8 TLC 1100 1450 5100 3100 DLC N₁₀L₃₀Abn₆₀ N₃₁L₆₉N₆₀L₃₄E₆ N₅₇L₂₇ E₁₀M₄ ESR 138 37 8 — Platelets 19000 258000 172000174000 2. VR/40 Hb gm % 5.6 8.2 9.6 10.0 TLC 1600 620 3200 3900 DLCN₃₅L₂₉E₂M₂ N₃₂L₂₂E₄M₂ N₄₀L₃₈E₄ N₇₃L₂₁ Abn₃₀ Abno₂₀ Abn₁₈ E₄M₂ ESR — — —— Platelets 40000 180000 200000 200000 3. PK/50 Hb gm % 10.2 9.3 10.113.9 TLC 2000 6800 7000 9000 DLC N₇L₁₀M₂Abn₈₁ N₇₀L₃₀ N₆₆L₃₃E₁ N₆₃L₃₇ ESR— — 10 — Plateltes 35000 25000 252000 330000 4. VC/48 Hb gm % 8.0 9.511.8 9.6 TLC 28000 650 7500 4800 DLC N₃₀L₃₅E₅M₄ N₂₀L₈₀ N₅₈L₂₆M₂ N₇₉L₁₃Abn₂₆ Abn₁₄ Abn₄ ESR 75 — — — Platelets 110000 22000 85000 120000 5.F/29 Hb gm % 9.0 9.0 5.0 9.6 TLC 4900 4900 2500 1000 DLC N₈L₄₇M₅Abn₄₀N₈L₄₅M₅ N₄₅L₅₄B₁ N₂₆L₅E₁ Abn₄₀ Abn₄₆ ESR — — 90 130 Platelets 7500075000 18000 55000 6. NS/15 Hb gm % 12.9 8.4 11.0 11.7 TLC 400 63200 79008500 DLC N₆₄L₃₆ N₅L₁₀Abn₈₅ N₅₇L₄₀E₃ N₆₀L₃₇E₃ ESR — 42 5 5 Platelets130000 64000 238000 218000 7. PR/48 Hb gm % 12.7 10.2 10.5 11.4 TLC 20003000 3500 5500 DLC N₇L₄₃Abn₅₀ N₁₃L₂₇E₄ N₄₈L₃₇E₆ N₅₅L₄₁ Abn₅₆ Abn₂B₁B₁Abn₂ ESR 43 — — — Platelets 76000 90000 298000 310000 8. MS/28 Hb gm %7.0 10.5 13.0 14.3 TLC 12200 5700 7200 9200 DLC N₈L₃₀Abn₆₂ N₅₅L₄₄E₁M₂N₇₃L₂₂E₅ N₆₄L₃₃E₃ ESR 48 5 — — Platelets 36000 103000 141000 169000 9.PS/29 Hb gm % 8.4 12.2 15.0 14.9 TLC 2240 2900 5200 4600 DLCN₁₅L₁₀M₅Abn₇₀ N₃₃ ₄L₅₀ N₄₆ ₉L₃₃ N₄₈ ₅E₂₄ ₄M₁₃ ₂E₈ ₃M₁₁ ₇L₃₀ ₄B₀ ₃ ₂B₀ ₄₅E₈ ₆M₁₂ ₁B₀₁ ESR — — 5 7 Platelets 25000 298000 202000 189000 10. MN/30Hb gm % 6.5 9.0 9.8 TLC 8200 7300 5600 DLC N₂₇L₄₈E₁ N₇₁L₂₃M₆ N₈₂L₁₇Abn₂₄ M₁ ESR — — 60 Platelets 120000 230000 150000 N-Neutrophils,L-Lymphocyte, E-Eosinophils, M-Monocyte, B-Basophil, Abn-Abnormal cell

DETAILS OF LIVER, KIDNEY FUNCTION AND LIPID PROFILE OF THE PATIENTSTREATED FOR ACUTE PROMYELOCYTIC LEUKEMIA Pre Ayurvedic treatment After90 days of Ayurvedic treatment S.no. Name/Age LFT Lipid profile KFT LFTLipid profile KFT 1. ARK/41 NA NA NA Bilirubin NA Blood - (T) - 1.2 23mgs/dl mg/dl Serum - Bilirubin(D) - 0.8 mg/dl 0.3 mg/dl creatinineProtein total - 7.8 mg/dl SGOT - 29, SGPT - 35 Alk.P. - 161 2. VR/40 NANA NA NA NA NA 3. PK/50 Bilirubin(T) - NA Blood urea - NA NA Blood - 04mgs/100 ml 21 mgs/ 34 mgs % Bilirubin(C) - 100 Serum serum 0.2 mgs/100ml creatinine - creatinine - SGOT - 75 u/l, 1.1 mgs/ 1.3 mgs % SGPT - 35100 ml Alk.P. - 324 u/l 4. VC/48 Bilirubin(T) - Total cholestrol - Bloodurea - Bilirubin(T) - Cholestrol - NA 0.7 mg % 168 mg/dl 26 mg % 0.72mg/dl 198 mg/dl Bilirubin(C) - HDL cholestrol - Serum Bilirubin(D) - 0.3mgs % 380 mg/dl creatinine - 0.3 mg/dl Protein total - VLDL cholestrol -1.0 mg % Protein total - 7.0 gm % 29 mg/dl Serum uric - 6.2 mg/dlAlbumin - 3.9 gm % LDL cholestrol - acid 4.9 Albumin - 3.6 Globulin -3.1 gm % 101 mg/dl mg % SGOT - 20 u/l, SGOT - 20 u/l, Triglyscerides -SGPT - 25 SGPT - 25 433 mg/dl Alk.P. - 430 Alk.P. - 138 5. F/29 NA NA NANA NA NA 6. NS/15 Bilirubin(T) - Total cholestrol - Blood sugar - NA NANA 0.5 mg/dl 185 mg % 90 mg % Bilirubin(D) - HDL cholestrol - Bloodurea - 0.3 mg/dl 42 mg % 19 mg % Protein total - VLDL cholestrol - Serumcreatinine - 7.1 g/dl 21 mg % 0.8 mg % Albumin - 3.4 g/dl LDLcholestrol - SGOT - 10 u/l, 122 mg % SGPT - 12 Triglyscerides - Alk.P. -103 105 mg % 7. PR/48 Bilirubin(T) - NA Blood - 34 mgs/ Bilirubin(T) -Total cholestrol - Blood urea - 1.57 mg/dl dl urea 0.6 mg % 198 mg/dl 17mg % Bilirubin(D) - Serum - 1.2 mg/ Bilirubin(D) - HDL cholestrol -Serum creatinine - 0.14 mg/dl dl creatinine 0.6 mg % 49 mg % 0.6 mg %Bilirubin(ID) - Uric - 2.8 mg/ Bilirubin(ID) - LDL cholestrol -Calcium - 1.43 mg/dl dl acid 0.5 mg % 150 mg % 9.7 mg % Protein total -Protein total - VLDL cholestrol - Phosphorus - 6.9 mg/dl 6.4 mg % 27 mg% 4.3 mg % SGOT - 29, SGPT - 22 Albumin - 3.7 mg % Triglyscerides -Sodium - 114 meg/l Alk.P. - 183.8 SGOT - 49 u/l, 136 mg % Chloride -SGPT - 38 u/l, 107 meg/l GGPT - 17 u/l Alk.P. - 17 u/l 8. MS/28 NA NA NABilirubin(T) - Total cholestrol - Blood urea - 0.5 mg/dl 146 mg/dl 33mg/dl Protein total - HDL cholestrol - Serum creatinine - 6.6 g/dl 32mg/dl 0.5 mg/dl Albumin - 4.2 LDL cholestrol - g/dl 53 mg/dl SGOT - 62u/l, Triglyacerides - SGPT - 138 u/l 306 mg/dl Alk.P. - 8 u/l 9. PS/29Bilirubin(T) - Total cholestrol - Blood urea - Bilirubin(T) - TotalBlood urea - 0.4 mg/dl 205 mg/dl 45 mg/dl 0.7 mg/dl cholestrol - 17mg/dl Bilirubin(D) - HDL cholestrol - Serum creat- Bilirubin(D) - 156mg/dl Serum creatinine - 0.2 mg/dl 31.25 mg/dl inine-0.90 0.2 mg/dl HDL1.0 mg/d Bilirubin(ID) - VLDL cholestrol - mg/dl Bilirubin(ID) -cholestrol - Calcium - 0.2 mg/dl 26.99% Calcium - 0.5 mg/dl 22.15 mg %9.7 mg/dl Protein total - LDL cholestrol 10.1 mg/dl Protein total - LDLcholestrol - Phosphorus - 7.6 g/dl 118.42 mg/dl Phosphorus - 7.7 g/dl94.09 mg % 2.9 mg/dl Albumin - 4.4 g/dl Triglyscerides - 4.1 mg/dlAlbumin - 4.6 g/dl VLDL Sodium - SGOT - 126 u/l, 433 mg/dl Sodium - 147SGOT - 253 u/l, cholestrol - 150 mE SGPT - 49 u/l mEq/l SGPT - 365 u/l27.35 mg % mEq/l GGTP - 38 u/l Chloride - GGTP - 89 u/l Trigly-Chloride - Alk.P. - 217 u/l 103 mEq/l Alk.P. - 473 u/l scerides - 105mEq/l Potassium - 187 mg/dl Potassium - 4.20 mEq/l 4.90 mEq/l 10. MN/30Bilirubin(T) - Total cholestrol - Blood urea Bilirubin(T) - Total Serumurea - 1.7 mg/dl 185 mg/dl 46 mg/dl 0.7 mg/dl cholestrol - 29.3 mg/dlBilirubin(D) - HDL cholestrol - Serum creatinine - Bilirubin(D) - 136.8mg/dl Serum creatinine - 1.13 mg/dl 26 mg/dl 1.05 mg/dl 0.3 mg/dl HDLcholestrol - 1.0 mg/dl Bilirubin(ID) - VLDL cholestrol - Calcium -SGOT - 22.8 iu/l 46.2 mg/dl 0.57 mg/dl 93 mg/dl 8.25 mg/dl SGPT - 27.6iu/l LDL cholestrol - SGOT - 28 u/l, LDL cholestrol Alk.P. - 360.5 56.5mg/dl SGPT - 35 u/l, 106 mg/dl iu/l VLDL cholestrol - Alk.P. - 229 u/lTriglyscerides - 34.1 mg/dl 506 mg/dl

1. A process for preparing an ayurvedic preparation, comprising thesteps of: subjecting silver, mercury, sulphur and arsenic trisulphide tothe steps of detoxification, grinding the detoxified mercury and silverin the presence of a citrus juice and then adding detoxified sulphur andagain subjecting to the steps of grinding to obtain a greyish blackpowder, adding adding detoxified arsenic trisulfide thereto andsubjecting to the step of grinding, imparting a shape such as a ballthereto, coating the ball with detoxified sulphur in the presence of acitrus juice and subjecting the coated ball to the step of slow firing,adding detoxified arsenic trisulphide and firing, repeating said stepsof addition and firing ground in a citrus juice such that the weight ofthe ball is reduced by at least 10% to obtain an intermediate, addingserpentive and delphenium root thereto.
 2. A process a claimed in claim1 wherein the coated balls are introduced into an earthen vessel, sealedand then fired in the presence of cow dung.
 3. A process as claimed inclaim 1 wherein silver is detoxified by heating silver sheets to a redhot state, and then introducing into sesame oil, subjecting the sheetsto repeated steps of heating and treatment with sesame oil.
 4. A processas claimed in claim 3 wherein the sesame treated silver is subjected torepetitive steps of heating and then treating with butter milk.
 5. Aprocess as claimed in claim 4 wherein the butter milk treated silver issubjected to repetitive steps of heating and then treating with cowurine.
 6. A process as claimed in claim 5 wherein the cow urine treatedsilver is then subjected to repetitive steps of heating and treatment ina herbal composition comprising amla, harar and bahera.
 7. A process asclaimed in claim 1 wherein the herbal treated silver is subjected torepetitive steps of heating and treatment with kulthi.
 8. A process asclaimed in claim 1 wherein the citrus juice is lemon juice.
 9. Theprocess as claimed in claim 3, wherein said repetitive steps comprise 7repetitive steps.
 10. A process as claimed in claim 1 wherein the stepof detoxification of mercury comprises in preparing an amalgam ofcopper, mercury and a citrus juice, subjecting such an amalgam torepeated steps of distillation to obtain detoxified mercury.
 11. Aprocess as claimed in claim 1 wherein the step of detoxification ofsulphur comprises in heating crystalline sulphur in the presence ofmelted butter, and then introducing into triffla to obtain a scum ofpure sulphur which is then removed therefrom.
 12. A process as claimedin claim 1 wherein the step of detoxification of arsenic trisulphidecomprises in wrapping arsenic trisulphide in cotton cloth and thenintroduced in a vessel of calcium oxide solution and into another vesselof pumpkin juice and boiled each time for a period of 3 to 5 hours. 13.A process as claimed in claim 1 wherein one part of detoxified silver isground with one part of detoxified mercury in a citrus juice and thatone part of detoxified sulphur is then added thereto obtain a greyishblack powder.
 14. A process as claimed in claim 12 wherein one part ofarsenic trisulphide ground in a citrus juice is added to the greyishblack powder and made into a shape.
 15. The process as claimed in claim14, wherein one part of detoxified sulphur is ground in citrus juice andcoated to said shape and then introduced in said vessel and fired incowdung.
 16. A process as claimed in claim 1 wherein vessel containingsaid fired mixture is opened and further arsenic trisulphide ground inthe presence of lemon juice is added, the vessel closed and again firedand subjected to repeated steps to obtain a potent preparation.